Huhu
Hier mal wissenschaftliche Studien zu dem Thema zitiert:
Das Jakobskrauzskraut ist
nicht giftig für Meerschweinchen:
Toxicity of Senecio jacobaea and pyrrolizidine alkaloids in various laboratory animals and avian species.
Cheeke, PR | Pierson-Goeger, ML
Toxicology Letters Vol. 18, no. 3, pp. 343-349. 1983.
The chronic toxicity of tansy ragwort (Senecio jacobaea ) to several herbivorous laboratory animals and to chicks and turkey poults was examined by feeding the dried plant as a component of a mixed diet. Gerbils, hamsters and guinea pigs were resistant to chronic toxicity. Gerbils were highly resistant, consuming over 3500% of their body weight of the dried plant, whereas susceptible species succumb to a tansy ragwort intake of 5-20% of their body weight. Guinea pigs and gerbils were resistant to the acute toxicity of injected monocrotaline, a pyrrolizidine alkaloid. They were moderately resistant to acute toxicity of injected tansy ragwort alkaloids. Both chicks and turkey poults were susceptible to chronic toxicity of dietary tansy ragwort.
Warum: weil Meerschweinchen ein spezielle Enzym haben, dass die Alkaloide deaktiviert:
A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig
Woon-Gye Chung; C. L. Miranda; D. R. Buhler
Xenobiotica: The fate and safety evaluation of foreign compounds in biological systems, 1366-5928, Volume 25, Issue 9, 1995, Pages 929 – 939
ABER:
Injiziert man den Meerschweinchen das Gift direkt, dann sterben auch sie an den Vergiftungen, aber erst aber einer Dosis von 526% des Körpergewicht (Vergleich Pferd: Pferd fällt bei 5% tot um)
Demnach sitzen die deaktivierenden Enzyme im Magen-Darmtrakt.
R. A. Swick, P. R. Cheeke, D. E. Goeger and D. R. Buhler
Effect of Dietary Senecio Jacobaea and Injected Senecio
Alkaloids and Monocrotaline on Guinea Pigs
J Anim Sci 1982. 55:1411-1416.
Grüße
Petra